What Is Tesamorelin?
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 44 amino acids with a trans-3-hexenoic acid modification. This modification enhances stability and bioavailability compared to native GHRH, making it valuable for studying the growth hormone axis.
Mechanism of Action
Tesamorelin binds to GHRH receptors on anterior pituitary somatotroph cells, stimulating endogenous growth hormone synthesis and pulsatile release. Unlike exogenous GH, tesamorelin preserves natural feedback mechanisms including somatostatin regulation.
Key aspects of its mechanism include pulsatile GH release maintaining natural secretion patterns, downstream IGF-1 elevation, preserved feedback loops, and physiological GH level increases within normal ranges.
Body Composition Research
Clinical trials have demonstrated significant reductions in visceral adipose tissue (VAT), with some studies showing approximately 15-18% VAT reduction over 26 weeks. These effects are mediated through GH’s lipolytic actions, particularly stimulation of hormone-sensitive lipase and fatty acid oxidation.
Metabolic Effects
Beyond body composition, tesamorelin research has revealed effects on triglyceride levels, inflammatory biomarkers like C-reactive protein, liver fat content, and potential cognitive benefits through IGF-1 mediated neuroprotection.
Research Applications
Full Scale Peptides provides Tesamorelin 10MG at 99%+ purity with full COA documentation for researchers studying growth hormone physiology, metabolic regulation, and body composition changes. For laboratory research use only.