What Is CJC-1295 (No DAC)?
CJC-1295 without Drug Affinity Complex (No DAC), also known as Modified GRF (1-29), is a synthetic analog of growth hormone-releasing hormone consisting of the first 29 amino acids of GHRH with four amino acid substitutions that improve metabolic stability.
How It Differs from CJC-1295 with DAC
The critical distinction is half-life. Without DAC, CJC-1295 has a half-life of approximately 30 minutes, producing discrete GH pulses that more closely mimic natural physiology. The DAC version extends half-life to 6-8 days, creating sustained GH elevation that doesn’t replicate normal pulsatile patterns.
Mechanism of Action
CJC-1295 (No DAC) binds to GHRH receptors on pituitary somatotrophs, triggering cAMP-mediated GH synthesis and release. The four amino acid substitutions (Ala2, Gln8, Ala15, Leu27) protect against enzymatic degradation while maintaining receptor binding affinity.
Research Applications
This compound is used in research studying pulsatile GH secretion patterns, GH axis physiology, the relationship between GH pulses and IGF-1 production, age-related changes in GH secretion, and combined protocols with GHRP compounds.
Advantages for Research
The short-acting nature of CJC-1295 (No DAC) allows researchers to study individual GH pulses and their downstream effects, something not possible with long-acting formulations. This makes it ideal for pharmacokinetic studies and protocols requiring precise timing control.
Laboratory Use
Full Scale Peptides provides CJC 1295 NO DAC 10MG at 99%+ purity. Store lyophilized at -20°C. Reconstitute with bacteriostatic water before use. For laboratory research use only.