Melanotan II (MT-II) is a synthetic, cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It is a non-selective agonist of the melanocortin receptors (MC1R, MC3R, MC4R, and MC5R).
### Mechanisms of Action
* **MC1R Activation:** Stimulates melanogenesis (the production of melanin) in melanocytes.
* **MC3R/MC4R Activation:** Modulates energy homeostasis, feeding behavior, and sexual function.
### Research Applications
* **Photoprotection:** MT-II was originally developed to study its potential to induce pigmentation without UV exposure, offering a model for photoprotection against UV-induced skin damage.
* **Sexual Dysfunction:** Due to its potent effects on the MC4 receptor, MT-II is utilized in research models of erectile dysfunction and female sexual arousal disorder.
* **Metabolic Regulation:** Its interaction with central melanocortin receptors makes it a subject of study in appetite suppression and energy expenditure.
*Disclaimer: Melanotan II is sold strictly for laboratory research use only. Not for human consumption.*