What Is VIP?
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide originally isolated from porcine intestine but now known to be widely distributed throughout the central and peripheral nervous systems. It belongs to the secretin/glucagon superfamily and signals through VPAC1 and VPAC2 receptors.
Neuroprotective Properties
VIP has demonstrated significant neuroprotective effects in multiple research models. It protects neurons against excitotoxicity, oxidative stress, and inflammatory damage. Studies in Parkinson’s and Alzheimer’s disease models have shown VIP can reduce neuronal death and preserve cognitive function.
Immune Modulation
VIP is a potent anti-inflammatory and immunomodulatory peptide. It shifts immune responses from Th1 (pro-inflammatory) toward Th2 (anti-inflammatory) profiles, inhibits macrophage activation, reduces pro-inflammatory cytokine production, and promotes regulatory T cell generation.
Circadian Rhythm Research
VIP plays a critical role in the suprachiasmatic nucleus (SCN), the brain’s master clock. It synchronizes circadian oscillations between SCN neurons and is essential for maintaining coherent circadian rhythms. VIP-deficient models show disrupted sleep-wake cycles.
Research Applications
Full Scale Peptides provides VIP 10MG at 99%+ purity. Store lyophilized at -20°C. For laboratory research use only.