What Is MOTS-c?
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial genome, representing a class of mitochondrial-derived peptides (MDPs). Discovered in 2015, it has been described as an exercise mimetic because it activates many of the same metabolic pathways triggered by physical exercise.
Mechanism of Action
MOTS-c primarily works through AMPK activation, the metabolic master switch that coordinates cellular responses to energy stress. When activated, AMPK triggers increased glucose uptake, enhanced fatty acid oxidation, inhibition of lipogenesis, mitochondrial biogenesis, and improved insulin sensitivity.
Metabolic Research Applications
In rodent models, MOTS-c administration has shown prevention of age-related insulin resistance, reduction in body weight gain on high-fat diets, improved glucose tolerance, enhanced physical performance, and reduced hepatic fat accumulation.
Aging Research
MOTS-c levels decline with age in both rodents and humans. Administration to aged mice improves physical capacity and metabolic parameters. Higher levels have been found in centenarians compared to age-matched controls, suggesting an association with exceptional longevity.
Laboratory Handling
MOTS-c should be stored lyophilized at -20°C. Full Scale Peptides provides MOTS-C 10MG at research grade with full COA documentation. For laboratory research use only.