What Is GLP-2?
Glucagon-like peptide-2 (GLP-2) is a 33-amino acid peptide produced by intestinal L-cells in response to nutrient intake. It acts as a specific intestinal growth factor, promoting mucosal proliferation, reducing apoptosis, and enhancing nutrient absorption. GLP-2 analogs with extended half-lives are valuable research tools for studying intestinal biology.
Intestinal Trophic Effects
GLP-2 signaling through the GLP-2 receptor produces remarkable intestinotrophic effects including increased villus height and crypt depth, enhanced mucosal surface area, improved nutrient absorptive capacity, increased intestinal blood flow, and reduced intestinal permeability.
Barrier Function Research
GLP-2 has been shown to strengthen the intestinal epithelial barrier by promoting tight junction protein expression, reducing inflammatory cytokine-induced permeability, enhancing mucus layer thickness, and supporting epithelial cell survival under stress.
Research Applications
GLP-2 analogs are used in research studying short bowel syndrome models, inflammatory bowel disease, intestinal adaptation after resection, mucosal healing mechanisms, and nutrient absorption physiology.
Laboratory Use
Full Scale Peptides provides GLP-2 TRZ at research grade with full COA documentation. Store lyophilized at -20°C. For laboratory research use only.